2-(Aminomethyl)-5-methylpyrazine → HCID 57749807, compound

HRID 77791Notes

Reaction equation

HRID 77791 reaction equation
[F:1][C:2]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][N:12]=2)=[CH:9][C:8]([N:18]2[C:22]([CH:23]([CH3:25])[CH3:24])=[N:21][N:20]=[N:19]2)=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:26][C:27]1[N:28]=[CH:29][C:30]([CH2:33][NH2:34])=[N:31][CH:32]=1>>[F:1][C:2]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][N:12]=2)=[CH:9][C:8]([N:18]2[C:22]([CH:23]([CH3:25])[CH3:24])=[N:21][N:20]=[N:19]2)=[CH:7][C:3]=1[C:4]([NH:34][CH2:33][C:30]1[CH:29]=[N:28][C:27]([CH3:26])=[CH:32][N:31]=1)=[O:6]

Participants

3

Reactant 2

HCID 27564962-(Aminomethyl)-5-methylpyrazineHCID 577497932-Fluoro-5-(5-isopropyl-tetrazol-1-yl)-3-(5-methyl-pyridin-2-yl)-benzoic acid

Product 1

HCID 57749807HCID 57749807, compound

Procedure

2-Fluoro-5-(5-isopropyl-tetrazol-1-yl)-3-(5-methyl-pyridin-2-yl)-benzoic acid was reacted with C-(5-methyl-pyrazin-2-yl)-methylamine using the procedure of step 4 of Example 7 to provide 2-fluoro-5-(5-isopropyl-tetrazol-1-yl)-N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-benzamide, MS (M+H)=447.

Sources & evidence

ORD record
ord-a31da4f013f54e8dbc29718c7566287d
Source dataset
uspto-grants-2014_09
Patent number
US08841336B2

Reaction notes

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