反应详情

温度

135 °C

A mixture of 2,6-dichloro-nicotinic acid (31 g, 0.14 mol) and 28% aqueous ammonia solution (200 mL) was stirred in a sealed tube for 10 hours at 135° C. This reaction solution was cooled to room temperature, and the excess ammonia gas was removed under a reduced pressure. Water was added to the residue to a total of 1000 mL, the mixture was cooled to 0° C., and citric acid was added to a pH being about 6. The precipitated solids were filtered out to obtain the title compound (12 g, 49%).

1. temperatureThis reaction solution was cooled to room temperature
2. customthe excess ammonia gas was removed under a reduced pressure
3. additionWater was added to the residue to a total of 1000 mL
4. temperaturethe mixture was cooled to 0° C.
5. additioncitric acid was added to a pH
6. filtrationThe precipitated solids were filtered out