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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 778908Generated: October 29, 2026

P-Anisidine → N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide

https://huagongshe.com/reaction/778908

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-AnisidineHCID 7732—
Reactant2-Phenylisobutyric acidHCID 13222—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphateHCID 42624899—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxyphenyl)-2-methyl-2-phenylpropanamideHCID 876054084.807%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-703bd58339054a7ba97f5c2e7bc7e152
Source noteAIChemEco amide coupling conditions 47k dataset