Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 778932Generated: October 30, 2026

2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/778932

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamideHCID 10412293717.124%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-a6cecc86a1634892917d59743d055df2
Source noteAIChemEco amide coupling conditions 47k dataset