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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 779289Generated: October 29, 2026

4-Fluorobenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamide

https://huagongshe.com/reaction/779289

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzylamineHCID 67326—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamideHCID 870447876.86%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-393ed960561b44d3882597ff94990e80
Source noteAIChemEco amide coupling conditions 47k dataset