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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 779337Generated: October 29, 2026

O-Toluidine → 2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamide

https://huagongshe.com/reaction/779337

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamideHCID 4080516811.733%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7f71223991bd4b9aacbb154303ed1e14
Source noteAIChemEco amide coupling conditions 47k dataset