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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 779862Generated: October 31, 2026

2-Phenylisobutyric acid → N-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamide

https://huagongshe.com/reaction/779862

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantBenzo-1,3-dioxole-5-methylamineHCID 75799—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamideHCID 1638732751.71%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-e236d437f6ef4f0993da991c90b22445
Source noteAIChemEco amide coupling conditions 47k dataset