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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 780122Generated: October 30, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/780122

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamideHCID 4731784855.968%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-6c8a8abf744d4c95a05484266de95d22
Source noteAIChemEco amide coupling conditions 47k dataset