反应详情

温度

0 °C

To a solution of (R)-2-hydroxy-3-phenylpropionic acid (1.5 g, 12.9 mol) in methanol (18 mL) at 0° C. was added concentrated sulfuric acid (0.2 mL). The reaction mixture was stirred at 0° C. for 30 min and warmed to room temperature for 24 h. Concentration in vacuo gave a residue which was diluted with diethyl ether (200 mL) and washed with water, saturated sodium bicarbonate and brine. The organic layer was separated, dried with sodium sulfate, filtered and concentrated in vacuo giving a white solid 1.62 g (85%), which was used without further purification.

1. temperaturewarmed to room temperature for 24 h
2. concentrationConcentration in vacuo
3. customgave a residue which
4. washwashed with water, saturated sodium bicarbonate and brine
5. customThe organic layer was separated
6. dry with materialdried with sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo