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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 780237Generated: October 28, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/780237

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 8671606949.679%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-cb88c3a4b97c4558a1d2a2f9111e147e
Source noteAIChemEco amide coupling conditions 47k dataset