4-((E)-2-furan-2-yl-vinyl)benzoic acid ethyl ester → 4-(2-Furan-2-yl-ethyl)-benzoic acid ethyl ester

Participants

Reaction Steps

To an anhydrous tetrahydrofuran (25 mL) solution of 4-((E)-2-furan-2-yl-vinyl)-benzoic acid ethyl ester (1.07 g, 4.4 mmol) described in Manufacturing Example 80-1-1 was added 10% palladium-carbon (50% hydrate, 500 mg), which was added for 2 hours under a hydrogen atmosphere at room temperature. The reaction product was filtered, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (t-butylmethyl ether: heptane=5:95) to obtain the title compound (706 mg, 65.4%).

Provenance & Evidence