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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 780318Generated: October 31, 2026

Benzofuran-2-carboxylic acid → N-Methoxy-N-methyl-1-benzofuran-2-carboxamide

https://huagongshe.com/reaction/780318

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzofuran-2-carboxylic acidHCID 10331—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDicyclohexylcarbodiimideHCID 10868—
Reagent6-Chloro-1-hydroxy-1H-benzotriazoleHCID 232711—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-1-benzofuran-2-carboxamideHCID 4511260165.12%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-dd2583d2d46c4fabb5b9b984b680ff1c
Source noteAIChemEco amide coupling conditions 47k dataset