(4-(2-(Tetrahydrofuran-2-yl)-ethyl)-phenyl)-methanol → 4-(2-(Tetrahydrofuran-2-yl)-ethyl)-benzaldehyde

Participants

Reaction Steps

To an ethyl acetate (50 mL) solution of (4-(2-(tetrahydrofuran-2-yl)-ethyl)-phenyl)-methanol (600 mg, 2.91 mmol) described in Manufacturing Example 82-1-2 was added active manganese dioxide (10 g, 115 mmol), which was stirred for 12 hours at room temperature. The reaction liquid was suction filtered through a Celite pad, and washed with ethyl acetate (50 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (565 mg, 95%).

Provenance & Evidence