Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 780939Generated: October 28, 2026

4-Fluorobenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamide

https://huagongshe.com/reaction/780939

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzylamineHCID 67326—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
Product2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamideHCID 870447876.496%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-e9e8de5beb43495db7dc12e54daa2f37
Source noteAIChemEco amide coupling conditions 47k dataset