反应详情

(5-Phenoxy-pyridin-2-yl)-methanol (300 mg, 1.5 mmol) described in Manufacturing Example 121-1-2, magnesium(IV) oxide (1.3 g, 15 mmol), and acetone (10 mL) were stirred under reflux for 20 minutes. More magnesium (IV) oxide (1.5 g, 17 mmol) was then added, which was stirred under reflux for another 20 minutes. The reaction solution was filtered through a Celite pad, and then the filtrate was concentrated under a reduced pressure to obtain the title compound (220 mg, 74%).

1. temperatureunder reflux for 20 minutes
2. stirringwhich was stirred
3. temperatureunder reflux for another 20 minutes
4. filtrationThe reaction solution was filtered through a Celite pad
5. concentrationthe filtrate was concentrated under a reduced pressure