反应详情

To a methylene chloride (20 mL) solution of (5-phenoxy-pyridin-3-yl)-methanol (756 mg, 3.76 mmol) described in Manufacturing Example 145-1-2 was added manganese(IV) dioxide (3.27 g, 37.6 mmol), which was stirred for 2 hours at room temperature. The insolubles were removed by filtrating through a Celite pad, after which the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane: ethyl acetate=2:1 to 1:1) to obtain the title compound (607 mg, 81%).

1. customThe insolubles were removed
2. filtrationby filtrating through a Celite pad
3. concentrationafter which the filtrate was concentrated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (heptane: ethyl acetate=2:1 to 1:1)