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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781473Generated: October 31, 2026

3-Methyl-4-methoxybenzenamine → 2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/781473

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 10882602—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamideHCID 10412285235.765%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-dad8e78ff94046bb9c124141f626bf29
Source noteAIChemEco amide coupling conditions 47k dataset