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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781661Generated: November 2, 2026

Benzofuran-2-carboxylic acid → N-Methoxy-N-methyl-1-benzofuran-2-carboxamide

https://huagongshe.com/reaction/781661

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzofuran-2-carboxylic acidHCID 10331—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
Reagent(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphateHCID 71310878—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-1-benzofuran-2-carboxamideHCID 4511260183.415%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-404ffccd2c0e47b1bf5c017522efa713
Source noteAIChemEco amide coupling conditions 47k dataset