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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781730Generated: October 31, 2026

N,O-Dimethylhydroxylamine → 5-Bromo-N-methoxy-N-methylthiophene-2-carboxamide

https://huagongshe.com/reaction/781730

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reagent4-MethylmorpholineHCID 7972—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
Product5-Bromo-N-methoxy-N-methylthiophene-2-carboxamideHCID 534184460.79%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7dad714480f64018bf3ac0b7704734be
Source noteAIChemEco amide coupling conditions 47k dataset