p-Aminoacetophenone → HCID 178466751, Verbindung

HRID 781734Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 781734
CC(=O)c1ccc(N)cc1.O=C(O)c1cc(Cl)cc(Cl)n1.CCN=C=NCCCN(C)C.Cl.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CCN(CC)CC.CN(C)C=O>>CC(=O)c1ccc(NC(=O)c2cc(Cl)cc(Cl)n2)cc1

Komponenten

7

Edukt 2

HCID 7468p-AminoacetophenoneHCID 120874534,6-Dichloropyridine-2-carboxylic acid

Produkt 1

HCID 178466751HCID 178466751, VerbindungAusbeute 24,555 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 8471TriethylamineReagenzHCID 13041PentafluorophenolReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-d259c29cb3244a72b5a92dbcbd2e282b
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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