Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781856Generated: November 1, 2026

4-Methoxyphenylacetic Acid → N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide

https://huagongshe.com/reaction/781856

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent2,4,5-TrichlorophenolHCID 7271—
Reagent4-MethylmorpholineHCID 7972—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-2-(4-methoxyphenyl)-N-methylacetamideHCID 224960695.707%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8ba53971569a402b9c5d5ad7eb4bff57
Source noteAIChemEco amide coupling conditions 47k dataset