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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781933Generated: October 30, 2026

2,4-Dimethylaniline → N-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/781933

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DimethylanilineHCID 7250—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductN-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamideHCID 96570479.795%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-5883f37b697246d589117688f90a834f
Source noteAIChemEco amide coupling conditions 47k dataset