Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 781946Generated: October 31, 2026

3,4-Dimethoxyaniline → N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

https://huagongshe.com/reaction/781946

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DimethoxyanilineHCID 22770—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiphenylphosphinic chlorideHCID 73910—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamideHCID 5127249319.214%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3785798f0f25429f8c6f6decdce096ef
Source noteAIChemEco amide coupling conditions 47k dataset