1h-Isoindol-1-one,2,3-dihydro-5-(4-nitrophenoxy)- → 1h-Isoindol-1-one,5-(4-aminophenoxy)-2,3-dihydro-

Participants

Reaction Steps

A slurry of 4-(1-isoindolinon-5-yloxy)-1-nitrobenzene (2.12 g, 7.8 mmol) and 10% Pd/C (0.20 g) in EtOH (50 mL) was stirred under an H2 atmosphere (balloon) for 4 h, then filtered through a pad of Celite®. The filtrate was concentrated under reduced pressure to afford 4-(1-oxoisoindolin-5-yloxy)aniline as a dark yellow solid: TLC (100% EtOAc) Rf 0.15.

Provenance & Evidence