HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-Chloro-N-methylpicolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | 4-Chloro-N-methylpicolinamide | HCID 1476814 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 4-Chloro-N-methylpicolinamide | HCID 1476814 | — |
| Product | 4-(4-Aminophenoxy)-N-methylpicolinamide | HCID 16655129 | — |
Reaction Steps
Entry 13: 4-Chloro-N-methyl-2-pyridinecarboxamide was synthesized according to Method A2, Step 3b. 4-Chloro-N-methyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 using DMAC in place of DMF to give 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline. According to Method C2a, 2-methoxy-5-(trifluoromethyl)aniline was reacted with CDI followed by 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline to afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841330B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ed396393bf1745368e5bad38161b2326 |
| Source note | uspto-grants-2014_09 |