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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78355Generated: October 26, 2026

2-Methoxy-5-(trifluoromethyl)aniline → 3-(4-Aminophenoxy)benzoic acid

https://huagongshe.com/reaction/78355

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxy-5-(trifluoromethyl)anilineHCID 600637—
ReactantBenzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)-HCID 11983909—
Reactant3-(4-Aminophenoxy)benzoic acidHCID 23009036—
Product3-(4-Aminophenoxy)benzoic acidHCID 23009036—
ProductN-(5-(trifluoromethyl)-2-methoxyphenyl)-N'-(3-carboxyphenyl)ureaHCID 23614600—

Reaction Steps

Entry 36: 4-(3-Carboxyphenoxy)aniline was synthesized according to Method A11. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 4-(3-Carboxyphenoxy)aniline was reacted with 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method C1f to afford N-(5-(trifluoromethyl)-2-methoxyphenyl)-N′-(3-carboxyphenyl)urea, which was coupled with 4-fluoroaniline according to Method D1c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841330B2
Source datasetuspto-grants-2014_09
ORD IDord-0d6d3c89f2ae44549d4065be26aaac3e
Source noteuspto-grants-2014_09