HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofurfurylamine → 3-(4-Nitrophenoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofurfurylamine | HCID 253298 | — |
| Reactant | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| Product | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| Product | 3-(4-nitrophenoxy)-N-(tetrahydro-2-furanylmethyl)benzamide | HCID 2986507 | — |
Reaction Steps
Entry 63: 4-(3-Carboxyphenoxy)-1-nitrobenzene was synthesized according to Method A13, Step 2. 4-(3-Carboxyphenoxy)-1-nitrobenzene was coupled with tetrahydrofurfurylamine according to Method A13, Step 3 to give 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene. According to Method A13 Step 4, 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline to afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841330B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-960654546b55426a858bdc82374e4060 |
| Source note | uspto-grants-2014_09 |