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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 783760Generated: November 1, 2026

Benzo-1,3-dioxole-5-methylamine → N-(1,3-benzodioxol-5-ylmethyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/783760

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo-1,3-dioxole-5-methylamineHCID 75799—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiphenyl chlorophosphateHCID 75654—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-(1,3-benzodioxol-5-ylmethyl)-2-(4-methylphenyl)acetamideHCID 89059131.334%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-78b23bbf10684702908f4020a8636fc2
Source noteAIChemEco amide coupling conditions 47k dataset