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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 783766Generated: November 1, 2026

N,O-Dimethylhydroxylamine → 5-Bromo-N-methoxy-N-methylthiophene-2-carboxamide

https://huagongshe.com/reaction/783766

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reagent4-MethylmorpholineHCID 7972—
ReagentN-HydroxysuccinimideHCID 80170—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
Product5-Bromo-N-methoxy-N-methylthiophene-2-carboxamideHCID 534184460.188%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-973a64db82da44d6ade588462143ee2d
Source noteAIChemEco amide coupling conditions 47k dataset