Butylamine → HCID 178449173, compound

HRID 78385Notes

Reaction equation

HRID 78385 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH:6]1([N:12]=[C:13]=[N:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[CH2:1]([NH:5][C:13]([NH:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=[N:12][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 10868Dicyclohexylcarbodiimide2×

Product 1

HCID 178449173HCID 178449173, compoundYield 99%

Procedure

A mixture of 15.69 g of N-butylamine (0.214 mol) and 22.13 g of dicyclohexylcarbodiimide (0.107 mol) is heated at reflux for 2 h. GC analysis then shows a conversion of the dicyclohexylcarbodiimide of greater than 99.6%. The final colorless mixture is concentrated at 60° C. under 1 mbar for 2 h to give 29.7 g of a colorless, virtually odorless and moderately viscous liquid corresponding to the expected guanidine 2 (99% yield).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 h
  3. concentrationThe final colorless mixture is concentrated at 60° C. under 1 mbar for 2 h

Sources & evidence

ORD record
ord-4693c0e579d94620970741d02ccecb0d
Source dataset
uspto-grants-2014_09
Patent number
US08841372B2

Reaction notes

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