反应详情

A mixture of 15.69 g of N-butylamine (0.214 mol) and 22.13 g of dicyclohexylcarbodiimide (0.107 mol) is heated at reflux for 2 h. GC analysis then shows a conversion of the dicyclohexylcarbodiimide of greater than 99.6%. The final colorless mixture is concentrated at 60° C. under 1 mbar for 2 h to give 29.7 g of a colorless, virtually odorless and moderately viscous liquid corresponding to the expected guanidine 2 (99% yield).

1. temperatureis heated
2. temperatureat reflux for 2 h
3. concentrationThe final colorless mixture is concentrated at 60° C. under 1 mbar for 2 h