HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2,2,3,3-Tetramethylcyclopropanecarboxylic acid [6-fluoro-3-(2-methoxyethyl)-3H-benzothiazol-2-ylidene]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | N-(6-fluoro-1,3-benzothiazol-2-yl)-2,2,3,3-tetramethylcyclopropanecarboxamide | HCID 86618903 | — |
| Solvent | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| Product | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid [6-fluoro-3-(2-methoxyethyl)-3H-benzothiazol-2-ylidene]-amide | HCID 68623016 | — |
Reaction Steps
To a solution of the product of Example 112A (1 equiv) in 1:1 DMF/THF (0.1 M) was added sodium hydride (60% dispersion in mineral oil, 1.2 equiv) and 2-bromoethyl methyl ether (1.2 equiv).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841334B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b0f6e5c438ab400daaa69330c3215cf9 |
| Source note | uspto-grants-2014_09 |