HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (5,6-dihydro-4H-cyclopentathiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid | HCID 152115 | — |
| Reactant | 3,4,5,6-Tetrahydro-2H-cyclopenta(d)(1,3)thiazol-2-imine | HCID 332255 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (5,6-dihydro-4H-cyclopentathiazol-2-yl)-amide | HCID 86618907 | — |
Reaction Steps
A mixture of 5,6-dihydro-4H-cyclopentathiazole-2-ylamine (177 mg, 1.26 mmol), 2,2,3,3-tetramethylcyclopropanecarboxylic acid (244 mg, 1.52 mmol), 4-dimethylaminopyridine (50.0 mg, 0.41 mmol) and triethylamine (351 μL, 2.52 mmol) in 20 mL of THF was processed according to the method of Example 118A to provide the title compound: MS (DCI/NH3) m/z 265 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841334B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f79d88940a2c47d181ea51aca7ee9166 |
| Source note | uspto-grants-2014_09 |