反应详情

A solution of 4-quinolinecarboxylic acid (Aldrich, 0.25 g, 1.4 mmol) in 5 mL of thionyl chloride was warmed to reflux and allowed to stir for 1 hour. The mixture was then cooled to ambient temperature and concentrated under reduced pressure. This material was dissolved in 10 mL toluene and concentrated under reduced pressure (3×) to afford the title compound.

1. temperatureto reflux
2. concentrationconcentrated under reduced pressure
3. dissolutionThis material was dissolved in 10 mL toluene
4. concentrationconcentrated under reduced pressure (3×)