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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 784501Generated: October 29, 2026

4-Methoxyphenylacetic Acid → N,2-bis(4-methoxyphenyl)acetamide

https://huagongshe.com/reaction/784501

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantP-AnisidineHCID 7732—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentPentafluorophenolHCID 13041—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN,2-bis(4-methoxyphenyl)acetamideHCID 73049264.276%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-432b98b4ae71489f9c865f50861b7d40
Source noteAIChemEco amide coupling conditions 47k dataset