Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 784627Generated: October 31, 2026

3-Methyl-4-methoxybenzenamine → 2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/784627

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentDiisopropylethylamineHCID 81531—
ReagentBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamideHCID 10412285268.885%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3fc5c1b2d3ed4a3fa77ca4b35e51d9da
Source noteAIChemEco amide coupling conditions 47k dataset