HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78467Generated: October 25, 2026
2-Amino-4-methylthiazole → Ammonium Hydroxide
https://huagongshe.com/reaction/78467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 4-methyl-3-((tetrahydro-2H-pyran-2-yl)methyl)thiazol-2(3H)-imine | HCID 68623127 | — |
Reaction Steps
A mixture of 2-amino-4-methylthiazole (1.0 g, 8.8 mmol) and 2-(bromomethyl)tetrahydropyran (1.1 mL, 8.8 mmol) was warmed to 85° C. and was allowed to stir for 24 hours. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 213 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08841334B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-66042b483df64b93849856760d56d233 |
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| Source note | uspto-grants-2014_09 |
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