HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78474Generated: October 29, 2026
1,3-Dioxolane, 2-(bromomethyl)- → Ammonium Hydroxide
https://huagongshe.com/reaction/78474
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Dioxolane, 2-(bromomethyl)- | HCID 78068 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-((1,3-dioxolan-2-yl)methyl)-5-methylthiazol-2(3H)-imine | HCID 68621817 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (1 g, 8.7 mmol) and 2-bromomethyl-1,3-dioxolane (0.98 mL, 9.6 mmol) was warmed to 85° C. and was allowed to stir for 18 hours. The mixture was cooled to ambient temperature and purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 201 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08841334B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-8624377caf9c4ae2a43f107bade81b5a |
|---|
| Source note | uspto-grants-2014_09 |
|---|
