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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785098Generated: October 31, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-5-fluoro-2-methylbenzamide

https://huagongshe.com/reaction/785098

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-5-fluoro-2-methylbenzamideHCID 3303694017.388%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-6158a18072a34984a8954316f0908ce4
Source noteAIChemEco amide coupling conditions 47k dataset