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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78512Generated: October 30, 2026

4-Toluenesulfonyl chloride → (S)-(5-Oxotetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate

https://huagongshe.com/reaction/78512

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
Reactant(S)-(+)-gamma-Hydroxymethyl-gamma-butyrolactoneHCID 2733813—
SolventPyridineHCID 1049—
Product(S)-(5-Oxotetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonateHCID 2724793—

Reaction Steps

A mixture of (S)-5-(hydroxymethyl)dihydrofuran-2(3H)-one, para-toluenesulfonyl chloride and pyridine were processed using the method described in Example 162A to afford the title compound. MS (ESI) m/z 288 (M+18)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841334B2
Source datasetuspto-grants-2014_09
ORD IDord-54eca40654f64d2e9a09976410959dd5
Source noteuspto-grants-2014_09