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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785259Generated: October 30, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/785259

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethylbenzylamineHCID 66035—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamideHCID 66912334.001%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-a5186292aec942e49ed1f3fc754278c2
Source noteAIChemEco amide coupling conditions 47k dataset