HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 5-tert-butyl-3-(2-((cis)-2,6-dimethylmorpholino)ethyl)thiazol-2(3H)-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 3,3-Dimethylbutanal | HCID 76335 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | 2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-amine | HCID 7144968 | — |
| Product | 5-tert-butyl-3-(2-((cis)-2,6-dimethylmorpholino)ethyl)thiazol-2(3H)-imine | HCID 68623640 | — |
Reaction Steps
Commercially available 3,3-dimethylbutanal (Aldrich), 4-(2-aminoethyl)-cis-2,6-dimethylmorpholine (Oakwood), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 315A to afford the title compound. MS (ESI+) m/z 298 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841334B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-36fc5c9db0d84a059829a33d35f48c22 |
| Source note | uspto-grants-2014_09 |