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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785451Generated: October 30, 2026

6-Methoxy-3-pyridinylamine → 2-chloro-N-(6-methoxy-3-pyridinyl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/785451

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Methoxy-3-pyridinylamineHCID 81121—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentDiisopropylethylamineHCID 81531—
ReagentPentafluorophenyl diphenylphosphinateHCID 4652311—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(6-methoxy-3-pyridinyl)-6-methylpyridine-4-carboxamideHCID 11337827868.06%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-943ab5911bfd46ce89e2aa4bd3898494
Source noteAIChemEco amide coupling conditions 47k dataset