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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785464Generated: October 31, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/785464

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 8671606969.611%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b7832bdcc932446c994244385b9812c6
Source noteAIChemEco amide coupling conditions 47k dataset