反应详情

To 3-amino-6-(3-pyridyl)pyrazine-2-carboxylic acid (2 g, 9.251 mmol) in MeOH (50 mL) was added conc. H2SO4 (907.3 mg, 493.1 μL, 9.251 mmol) and the mixture heated to reflux for 2 hours. The solvent was removed in vacuo and the mixture neutralised with aq. Na2CO3. The resulting brown solid was collected by filtration and dried (2.08 g, 97% Yield). MS (ES+) 231

1. temperaturethe mixture heated
2. temperatureto reflux for 2 hours
3. customThe solvent was removed in vacuo
4. filtrationThe resulting brown solid was collected by filtration
5. customdried (2.08 g, 97% Yield)