Methanol → HCID 59471788, compound

HRID 78565Notes

Reaction equation

HRID 78565 reaction equation
[NH2:1][C:2]1[C:3]([C:14]([OH:16])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1.OS(O)(=O)=O.[CH3:22]O>>[NH2:1][C:2]1[C:3]([C:14]([O:16][CH3:22])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 594721543-Amino-6-(pyridin-3-yl)pyrazine-2-carboxylic acid

Product 1

HCID 59471788HCID 59471788, compoundYield 97%

Procedure

To 3-amino-6-(3-pyridyl)pyrazine-2-carboxylic acid (2 g, 9.251 mmol) in MeOH (50 mL) was added conc. H2SO4 (907.3 mg, 493.1 μL, 9.251 mmol) and the mixture heated to reflux for 2 hours. The solvent was removed in vacuo and the mixture neutralised with aq. Na2CO3. The resulting brown solid was collected by filtration and dried (2.08 g, 97% Yield). MS (ES+) 231

Workup

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe solvent was removed in vacuo
  4. filtrationThe resulting brown solid was collected by filtration
  5. customdried (2.08 g, 97% Yield)

Sources & evidence

ORD record
ord-8282d7038caf4e1194a7dd66edba6051
Source dataset
uspto-grants-2014_09
Patent number
US08841308B2

Reaction notes

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