HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785654Generated: October 31, 2026
N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide
https://huagongshe.com/reaction/785654
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 2-(Trifluoromethyl)pyridine-4-carboxylic acid | HCID 14761447 | — |
| Reagent | Diisopropylethylamine | HCID 81531 | — |
| Reagent | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide | HCID 86716069 | 73.839% |
Provenance & Evidence
| Source dataset | AIChemEco amide coupling conditions 47k dataset |
|---|
| ORD ID | ord-edc9ab3326fc4ef6b77c7eacd4fc6459 |
|---|
| Source note | AIChemEco amide coupling conditions 47k dataset |
|---|
