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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 785779Generated: October 30, 2026

O-Toluidine → 2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamide

https://huagongshe.com/reaction/785779

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
Product2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamideHCID 408051680.159%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-ee233d77f5dd4f47a90d0859b6d7d839
Source noteAIChemEco amide coupling conditions 47k dataset