HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78581Generated: October 26, 2026
Hydrochloric Acid → 3-Amino-6-bromopyrazine-2-carboxylic acid
https://huagongshe.com/reaction/78581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-Amino-6-bromopyrazine-2-carboxylate | HCID 227251 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Amino-6-bromopyrazine-2-carboxylic acid | HCID 18521600 | 99% |
Reaction Steps
A mixture of methyl 3-amino-6-bromo-pyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) in MeOH (20 mL) and H2O (20 mL) was heated to 90° C. for 2 hours. The reaction mixture was allowed to cool and neutralised with HCl and the resultant precipitate collected by filtration. Taken on to the next step without further purification (4.80 g, 99% Yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08841308B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-b77f463d521b4c8f9bd4a22919f5bc73 |
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| Source note | uspto-grants-2014_09 |
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