Methanol → HCID 59471788, compound

HRID 78604Notes

Reaction equation

HRID 78604 reaction equation
[NH2:1][C:2]1[C:3]([C:14]([OH:16])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1.OS(O)(=O)=O.[CH3:22]O>>[NH2:1][C:2]1[C:3]([C:14]([O:16][CH3:22])=[O:15])=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 594721543-Amino-6-(pyridin-3-yl)pyrazine-2-carboxylic acid

Product 1

HCID 59471788HCID 59471788, compoundYield 97%

Procedure

To 3-amino-6-(3-pyridyl)pyrazine-2-carboxylic acid (2 g, 9.251 mmol) in MeOH (50 mL) was added conc. H2SO4 (907.3 mg, 493.1 μL, 9.251 mmol) and the mixture heated to reflux for 2 hours. The solvent was removed under vacuum and the mixture neutralised with aqueous Na2CO3 and the resulting solid collected by filtration and dried to give the desired product (2.08 g, 97% Yield). MS (ES+) 231.87

Workup

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe solvent was removed under vacuum
  4. filtrationthe resulting solid collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-9241c756daf14a6c8bb10628986c1adb
Source dataset
uspto-grants-2014_09
Patent number
US08841308B2

Reaction notes

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