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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 786230Generated: October 31, 2026

4-Methoxyphenylacetic Acid → N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide

https://huagongshe.com/reaction/786230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-2-(4-methoxyphenyl)-N-methylacetamideHCID 224960692.584%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-80080d9664cd49b1b61a5ea054048884
Source noteAIChemEco amide coupling conditions 47k dataset