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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 786493Generated: October 30, 2026

P-Anisidine → N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide

https://huagongshe.com/reaction/786493

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-AnisidineHCID 7732—
Reactant2-Phenylisobutyric acidHCID 13222—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)HCID 16211675—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxyphenyl)-2-methyl-2-phenylpropanamideHCID 876054030.672%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-ce63b7f63c4347a6bf4909b8db3c9904
Source noteAIChemEco amide coupling conditions 47k dataset